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Indeed, some metabotypes have been found more frequently in patients with specific diseases leading to microbiome dysbiosis such as metabolic syndrome or obesity (Reference Toms-Barbern, Selma and Espn110) , although this has not been fully confirmed in larger cohorts

Consequently, this structural preservation effectively limits the infiltration of peripheral immune cells, such as T-cells and neutrophils, into the brain parenchyma, thereby significantly attenuating downstream neuroinflammatory responses (Jayanti et al., 2022

Specific Application In affinity chromatography process: The target proteins are reversibly and specifically bound to the complementary binding substance(ligand)